<p> This entry represents one of two subunits/domains of the bifunctional isomerase/decarboxylase involved in 4-hydroxyphenylacetate degradation [<cite idref="PUB00016709"/>]. In <taxon tax_id="562">Escherichia coli</taxon> and some other species, this enzyme is encoded by a single polypeptide containing both this domain and the closely related N-terminal domain (<db_xref db="INTERPRO" dbkey="IPR012686"/>). In other species such as <taxon tax_id="747">Pasteurella multocida</taxon>, these domains are found as two separate proteins (usually as tandem genes). Together, these domains carry out the decarboxylation of 5-oxopent-3-ene-1,2,5-tricarboxylic acid (OPET) to 2-hydroxy-2,4-diene-1,7-dioate (HHDD) and the subsequent isomerization to 2-oxohept-3-ene-1,7-dioate (OHED).</p> 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit